Tigecycline – 15 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 15 micrograms of tigecycline, a glycylcycline antibiotic. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to tigecycline.

Tigecycline is a broad-spectrum antibiotic, meaning that it is effective against a wide range of bacteria, including both Gram-positive and Gram-negative bacteria. It is used to treat a variety of infections, including:

• Intra-abdominal infections
• Skin and soft tissue infections
• Bone and joint infections
• Respiratory infections
• Urinary tract infections
• Sepsis
• Meningitis

Tigecycline is also used to prevent infections before surgery.

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 19 mm | Susceptible | | 16-18 mm | Intermediate | | < 16 mm | Resistant |

Limitations:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to tigecycline. For example, some strains of Acinetobacter baumannii are resistant to tigecycline, but they may not produce a zone of inhibition around a tigecycline disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Important safety information:

• Tigecycline is a potent antibiotic, and it can cause a number of side effects, including:

  • Nausea
  • Vomiting
  • Diarrhea
  • Abdominal pain
  • Headache
  • Dizziness
  • Rash
  • Liver damage
  • Kidney damage
  • Allergic reactions, including anaphylaxis

• Tigecycline can also interact with other medications, so it is important to tell your doctor or pharmacist about all of the medications you are taking before starting tigecycline.

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