The Ketoconazole – 10 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 10 micrograms of ketoconazole, an antifungal medication. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of fungi to ketoconazole.

The disc diffusion method is a simple and inexpensive method for testing the susceptibility of fungi to antifungal medications. It is based on the principle that fungi that are susceptible to an antifungal medication will not be able to grow near the disc containing the antifungal medication.

To perform the disc diffusion test, a fungal suspension is spread on the surface of an agar plate. Antifungal discs are then placed on the surface of the agar plate. The plates are incubated for 24-48 hours, and then the zones of inhibition around the discs are measured. The size of the zone of inhibition is proportional to the susceptibility of the fungi to the antifungal medication.

The Ketoconazole – 10 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of a wide range of fungal infections, including:

• Candidiasis (yeast infections)
• Dermatophytoses (ringworm, athlete’s foot, etc.)
• Tinea versicolor
• Seborrheic dermatitis
• Pityriasis capitis (dandruff)
• Onychomycosis (nail fungus)

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 16 mm | Susceptible | | 10-15 mm | Intermediate | | < 10 mm | Resistant |

It is important to note that the disc diffusion method is only a semi-quantitative method for testing the susceptibility of fungi to antifungal medications. For more accurate results, other methods such as broth microdilution or agar dilution should be used.

The Ketoconazole – 10 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of a wide range of fungal infections. However, it is important to be aware of the potential side effects of ketoconazole before using it. Ketoconazole can cause side effects such as nausea, vomiting, diarrhea, and rash. In rare cases, ketoconazole can cause serious side effects such as liver damage and adrenal insufficiency.

Limitations of the Ketoconazole – 10 μg Antibiotic Disc – Bioanalyse:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of fungi to antifungal medications. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all fungi that are resistant to ketoconazole. For example, some strains of Candida albicans are resistant to ketoconazole, but they may not produce a zone of inhibition around a ketoconazole disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Additional information about ketoconazole:

Ketoconazole is an imidazole antifungal medication. Imidazole antifungal medications are effective against a wide range of fungi, including both yeasts and molds. Ketoconazole is a fungistatic medication, which means that it prevents fungi from growing.

Ketoconazole is a safe and effective antifungal medication for most people. However, it is important to be aware of the potential side effects of ketoconazole before using it. Ketoconazole is not recommended for people who are allergic to ketoconazole or for people with liver problems.

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