Nitrofurantoin – 300 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 300 micrograms of nitrofurantoin, a nitrofuran antibiotic. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to nitrofurantoin.

Nitrofurantoin is a narrow-spectrum antibiotic, meaning that it is only effective against a limited range of bacteria. It is primarily used to treat urinary tract infections caused by Gram-negative bacteria such as Escherichia coli and Enterococcus faecalis. Nitrofurantoin is also used to prevent urinary tract infections in people who are prone to them.

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 17 mm | Susceptible | | 13-16 mm | Intermediate | | < 13 mm | Resistant |

It is important to note that the disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.

The Nitrofurantoin – 300 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of urinary tract infections. However, it is important to be aware of the potential side effects of nitrofurantoin before using it. Nitrofurantoin can cause side effects such as:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Rash

In rare cases, nitrofurantoin can cause serious side effects such as:

• Liver damage
• Peripheral neuropathy (damage to the nerves in the hands and feet)
• Pulmonary fibrosis (scarring of the lungs)

Limitations of the Nitrofurantoin – 300 μg Antibiotic Disc – Bioanalyse:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to nitrofurantoin. For example, some strains of Escherichia coli are resistant to nitrofurantoin, but they may not produce a zone of inhibition around a nitrofurantoin disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Additional information about nitrofurantoin:

Nitrofurantoin is a safe and effective antibiotic for most people when used as directed. However, it is important to be aware of the potential side effects of nitrofurantoin before using it. Nitrofurantoin is not recommended for people who are allergic to nitrofurantoin or other nitrofuran antibiotics. Nitrofurantoin is also not recommended for people with kidney problems or liver problems. Nitrofurantoin is also not recommended for pregnant women or breastfeeding women.

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