Novobiocin – 30 μg Antibiotic Disc – Bioanalyse is a paper disc impregnated with 30 micrograms of novobiocin, a coumarin antibiotic. It is used in the disc diffusion method of antimicrobial susceptibility testing to determine the susceptibility of bacteria to novobiocin.

Novobiocin is a narrow-spectrum antibiotic, meaning that it is only effective against a limited range of bacteria. It is primarily used to treat infections caused by staphylococci, such as Staphylococcus aureus and Staphylococcus epidermidis. Novobiocin is also used to treat some strains of Streptococcus pneumoniae and Enterococcus faecalis.

Interpretation of results:

| Zone of inhibition | Interpretation | |—|—|—| | ≥ 21 mm | Susceptible | | 16-20 mm | Intermediate | | < 16 mm | Resistant |

It is important to note that the disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.

The Novobiocin – 30 μg Antibiotic Disc – Bioanalyse is a valuable tool for the diagnosis and treatment of infections caused by staphylococci and other susceptible bacteria. However, it is important to be aware of the potential side effects of novobiocin before using it. Novobiocin can cause side effects such as:

• Nausea
• Vomiting
• Diarrhea
• Abdominal pain
• Headache
• Dizziness
• Rash

In rare cases, novobiocin can cause serious side effects such as:

• Liver damage
• Jaundice
• Agranulocytosis (a decrease in the number of white blood cells)

Limitations of the Novobiocin – 30 μg Antibiotic Disc – Bioanalyse:

• The disc diffusion method is only a semi-quantitative method for testing the susceptibility of bacteria to antibiotics. For more accurate results, other methods such as broth microdilution or agar dilution should be used.
• The disc diffusion method is not able to detect all bacteria that are resistant to novobiocin. For example, some strains of Staphylococcus aureus are resistant to novobiocin, but they may not produce a zone of inhibition around a novobiocin disc.
• The disc diffusion method can be affected by the type of agar plate used, the incubation temperature, and the inoculum density. Therefore, it is important to follow standardized procedures when performing the disc diffusion test.

Additional information about novobiocin:

Novobiocin is a safe and effective antibiotic for most people when used as directed. However, it is important to be aware of the potential side effects of novobiocin before using it. Novobiocin is not recommended for people who are allergic to novobiocin or other coumarin antibiotics. Novobiocin is also not recommended for pregnant women or breastfeeding women.

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